Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis.

Abstract excerpt

Transcriptional activation by c-Myc through specific E box elements is thought to be essential for its biological role. However, c-MycS is unable to activate transcription through these elements and yet retains the ability to stimulate proliferation, induce anchorage-independent growth, and induce apoptosis. In addition, c-MycS retains the ability to repress transcription of several specific promoters....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Division
• Share to Cell Line
• Share to Cell Transformation, Neoplastic