Article
Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis.
Genes & development - 15 Dec 1998
Xiao Q, Claassen G, Shi J, Adachi S, Sedivy J, Hann S R
Abstract excerpt
Transcriptional activation by c-Myc through specific E box elements is thought to be essential for its biological role. However, c-MycS is unable to activate transcription through these elements and yet retains the ability to stimulate proliferation, induce anchorage-independent growth, and induc...
Topics
- 3T3 Cells
- Animals
- Apoptosis
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Genes, myc
- Genes, p53
- Intracellular Signaling Peptides and Proteins
- Membrane Glycoproteins
- Mice
- Ornithine Decarboxylase
- Phenotype
- Protein Isoforms
- Protein Precursors
- Proteins