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Article

Resistance to transformation by insertionally activated c-erbB is a dominant phenotype in fibroblasts.

Virology - 10 Sept 1995

Carter T H, Dominguez N, Zeng L, Kung H J

Abstract excerpt

Tissue-specific factors influence whether cells are susceptible to transformation by erbB oncogenes. Avian fibroblasts resist transformation by insertionally activated c-erbB (IAc-erbB), whereas erythroblasts are transformed by this mutant of the epidermal growth factor receptor. In studies presented here, NIH/3T3 cells resisted transformation by IAc-erbB. This finding indicates that the nonpermissiveness of...

Topics

3T3 Cells
Alleles
Animals
Base Sequence
Cell Transformation, Neoplastic
DNA Primers
Fibroblasts
Genes, Dominant
Genes, erbB-2
Mice
Molecular Sequence Data
Oncogenes

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Identifiers

PMID: 7676646
DOI: 10.1006/viro.1995.1484

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7676646-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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