Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.

doi:10.1093/hmg/ddq041

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.

Human molecular genetics - 1 May 2010

Prescott Natalie J, Dominy Katherine M, Kubo Michiaki, Lewis Cathryn M, Fisher Sheila A, Redon Richard, Huang Ni, Stranger Barbara E, Blaszczyk Katarzyna, Hudspith Barry, Parkes Gareth, Hosono Naoya, Yamazaki Keiko, Onnie Clive M, Forbes Alastair, Dermitzakis Emmanouil T, Nakamura Yusuke, Mansfield John C, Sanderson Jeremy, Hurles Matthew E, Roberts Roland G, Mathew Christopher G

Abstract excerpt

DNA polymorphisms in a region on chromosome 5q33.1 which contains two genes, immunity related GTPase related family, M (IRGM) and zinc finger protein 300 (ZNF300), are associated with Crohn's disease (CD). The deleted allele of a 20 kb copy number variation (CNV) upstream of IRGM was recently shown to be in strong linkage disequilibrium (LD) with the CD-associated single nucleotide polymorphisms and is itself...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crohn Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to GTP-Binding Proteins

Share to INDEL Mutation

Share to Logistic Models

Share to Oligonucleotide Array Sequence Analysis

Share to United Kingdom

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 20106866
DOI: 10.1093/hmg/ddq041
PMCID: PMC2850616

Genes

IRGM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.PMID 20106866Read ↗

Crohn’s disease IRGM risk alleles are associated with altered gene expression in human tissuesSemantic proximity Read ↗

Correlation between IRGM genetic polymorphisms and Crohn's disease risk: a meta-analysis of case-control studies.Semantic proximity Read ↗

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.Semantic proximity Read ↗

On the level: IRGM gene function is all about expression.Semantic proximity Read ↗

Associations between genetic variants in the IRGM gene and inflammatory bowel diseases in the Korean population.Semantic proximity Read ↗

Association of IRGM gene mutations with inflammatory bowel disease in the Indian population.Semantic proximity Read ↗

A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.Semantic proximity Read ↗

Polymorphism of the IRGM gene might predispose to fistulizing behavior in Crohn's disease.Semantic proximity Read ↗

Association between variants of the autophagy related gene--IRGM and susceptibility to Crohn's disease and ulcerative colitis: a meta-analysis.Semantic proximity Read ↗

Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients.Semantic proximity Read ↗

Race-specific association of an IRGM risk allele with cytokine expression in human subjects.Semantic proximity Read ↗

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.