Article
Polymorphism of the IRGM gene might predispose to fistulizing behavior in Crohn's disease.
The American journal of gastroenterology - 1 Jan 2009
Latiano A, Palmieri O, Cucchiara S, Castro M, D'Incà R, Guariso G, Dallapiccola B, Valvano M R, Latiano T, Andriulli A, Annese V
Abstract excerpt
OBJECTIVES: Recently, genome-wide association analyses have identified single nucleotide polymorphisms in the IRGM gene (rs1000113 and rs4958847) as strong candidate susceptibility factors for Crohn's disease (CD). The aim of our study was to test whether these variants are associated with inflammatory bowel disease (IBD) in adult- and childhood-onset Italian patients. METHODS: Allele and genotype frequencies of...
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