A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.

doi:10.1136/gutjnl-2012-302865

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Article

A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.

Gut - 1 Oct 2013

Julià Antonio, Domènech Eugeni, Ricart Elena, Tortosa Raül, García-Sánchez Valle, Gisbert Javier P, Nos Mateu Pilar, Gutiérrez Ana, Gomollón Fernando, Mendoza Juan Luís, Garcia-Planella Esther, Barreiro-de Acosta Manuel, Muñoz Fernando, Vera Maribel, Saro Cristina, Esteve Maria, Andreu Montserrat, Alonso Arnald, López-Lasanta María, Codó Laia, Gelpí Josep Lluís, García-Montero Andres C, Bertranpetit Jaume, Absher Devin, Panés Julián, Marsal Sara

Abstract excerpt

OBJECTIVE: Genome-wide association studies (GWAS) have identified multiple risk loci for Crohn's disease (CD). However, the cumulative risk exerted by these loci is low, and the likelihood that additional, as-yet undiscovered loci contribute to the risk of CD is very high. We performed a GWAS on a southern European population to identify new CD risk loci. DESIGN: We genotyped 620 901 genome markers on 1341 CD...

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Identifiers

PMID: 22936669
DOI: 10.1136/gutjnl-2012-302865

Genes

RBX1
AIF1
FOXP2
IFNGR2
MACROD2

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