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Article

The p.T216R mutation of the thromboxane A2 receptor disrupts platelet function by selectively altering the G12/13 signaling pathway.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2026

Denis Kevin, Heim Véronique, Fiore Mathieu, Laeufer Patricia, Eckly Anita, Yoann Huguenin, Desprez Dominique, Mangin Pierre, Hechler Beatrice, Dupuis Arnaud, Strassel Catherine

Abstract excerpt

BACKGROUND: The thromboxane A2 receptor (TBXA2R) is a platelet receptor that binds to 2 distinct G protein signaling pathways (Gq and Gα12/13) and plays a major role in platelet activation. Mutations in the TBXA2R gene can alter platelet aggregation and cause bleeding disorders. Until now, only mutations affecting the Gq pathway have been reported. OBJECTIVES: This study aimed to characterize a new TBXA2R gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GTP-Binding Protein alpha Subunits, G12-G13

Share to GTP-Binding Protein alpha Subunits, Gq-G11

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Source

Identifiers

PMID: 41990920
DOI: 10.1016/j.jtha.2026.03.027

Genes

TBXA2R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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