Article
Identification of a Distinct Platelet Phenotype in the Elderly: ADP Hypersensitivity Coexists With Platelet PAR (Protease-Activated Receptor)-1 and PAR-4-Mediated Thrombin Resistance.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2022
Gnanenthiran Sonali R, Pennings Gabrielle J, Reddel Caroline J, Campbell Heather, Kockx Maaike, Hamilton Justin R, Chen Vivien M, Kritharides Leonard
Abstract excerpt
BACKGROUND: Thrombin (via PAR [protease-activated receptor]-1 and PAR-4) and ADP (via P2Y12 receptors) are potent endogenous platelet activators implicated in the development of cardiovascular disease. We aimed to assess whether platelet pathways alter with aging. METHODS: We characterized platelet activity in community-dwelling volunteers (n=174) in the following age groups: (1) 20 to 30 (young); (2) 40 to 55...
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