Article
Identification of a Distinct Platelet Phenotype in the Elderly: ADP Hypersensitivity Coexists With Platelet PAR (Protease-Activated Receptor)-1 and PAR-4-Mediated Thrombin Resistance.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2022
Gnanenthiran Sonali R, Pennings Gabrielle J, Reddel Caroline J, Campbell Heather, Kockx Maaike, Hamilton Justin R, Chen Vivien M, Kritharides Leonard
Abstract excerpt
BACKGROUND: Thrombin (via PAR [protease-activated receptor]-1 and PAR-4) and ADP (via P2Y12 receptors) are potent endogenous platelet activators implicated in the development of cardiovascular disease. We aimed to assess whether platelet pathways alter with aging. METHODS: We characterized platel...
Topics
- Adenosine Diphosphate
- Aged
- Blood Platelets
- Calcium
- Cardiovascular Diseases
- Humans
- Inflammation
- Interleukin-6
- P-Selectin
- Phenotype
- Platelet Activation
- Platelet Aggregation
- Receptor, PAR-1