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Article

The platelet fibrinogen receptor: from megakaryocyte to the mortuary

1 May 2012

Abstract excerpt

Platelets are integral to normal haemostatic function and act to control vascular haemorrhage with the formation of a stable clot. The fibrinogen receptor (glycoprotein IIb/IIIa [GPIIb/IIIa]) is the most abundant platelet integrin and, by binding fibrinogen, facilitates irreversible binding of platelets to the exposed extracellular matrix and enables the cross-linking of adjacent platelets. The vital role of...

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Identifiers

PMID: 24175064
DOI: 10.1258/cvd.2012.012007

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