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Polymorphisms involved in folate metabolism pathways and the risk of the development of childhood acute leukemia.

Genetic testing and molecular biomarkers - 1 Feb 2013

Silva Rafaela Maria Seabra, Fontes Alide Caroline Lima, Silva Karina Alves, Sant'Ana Thalita Araújo, Ramos Flávio José da Costa, Marques-Salles Terezinha de Jesus, Pombo-de-Oliveira Maria S, Muniz Maria Tereza Cartaxo

Abstract excerpt

OBJECTIVE: Polymorphisms that reduce the activity of reduced folate carrier (RFC) and methylenetetrahydrofolate reductase (MTHFR) and double (2R2R) or triple (3R3R) 28-bp tandem repeats in the promoter region of thymidylate synthase (TS) have been associated with the risk of childhood acute leukemia (AL). A case-control genotyping study was conducted in Brazilian children with the aim of investigating RFC, MTHFR,...

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Share to Child, Preschool
Share to Folic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Restriction Fragment Length

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Replication Protein C

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Source

Identifiers

PMID: 23336575
DOI: 10.1089/gtmb.2012.0174

Genes

MTHFR

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