Creation and characterization of temperature-sensitive CENP-C mutants in vertebrate cells.

doi:10.1093/nar/29.18.3796

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Article

Creation and characterization of temperature-sensitive CENP-C mutants in vertebrate cells.

Nucleic acids research - 15 Sept 2001

Fukagawa T, Regnier V, Ikemura T

Abstract excerpt

CENP-C is an evolutionarily conserved centromere protein that is thought to be an important component in kinetochore assembly in vertebrate cells. However, the functional role of CENP-C in cell cycle progression remains unclear. To further understand CENP-C function, we developed a method incorporating the hyper-recombinogenic chicken B lymphocyte cell line DT40 to create several temperature-sensitive CENP-C...

Topics

Animals
Base Sequence
Cell Division
Cell Survival
Centromere
Chickens
Chromosomal Proteins, Non-Histone
Humans
Mutation
Phenotype
Plasmids
SUMO-1 Protein
Suppression, Genetic
Temperature
Time Factors
Transfection
Ubiquitins

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Identifiers

PMID: 11557811
DOI: 10.1093/nar/29.18.3796
PMCID: PMC55920

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