Article
Point mutations that separate the role of Saccharomyces cerevisiae centromere binding factor 1 in chromosome segregation from its role in transcriptional activation.
Genetics - 1 Oct 1993
Foreman P K, Davis R W
Abstract excerpt
Centromere binding factor 1 (Cbf1p or CP1) binds to the CDEI region of Saccharomyces cerevisiae centromeres and is a member of the basic helix-loop-helix (bHLH) class of proteins. Deletion of the gene encoding Cbf1p results in an increased frequency of chromosome loss, hypersensitivity to low lev...
Topics
- Base Sequence
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Centromere
- Chromosomes, Fungal
- DNA Primers
- DNA-Binding Proteins
- Fungal Proteins
- Genes, Fungal
- Genotype
- Helix-Loop-Helix Motifs
- Molecular Sequence Data
- Plasmids
- Point Mutation
- Polymerase Chain Reaction
- Restriction Mapping
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transcription, Genetic