Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes.

doi:10.1128/mcb.10.1.223-234.1990

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Article

Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes.

Molecular and cellular biology - 1 Jan 1990

Hoyt M A, Stearns T, Botstein D

Abstract excerpt

By using a multiply marked supernumerary chromosome III as an indicator, we isolated mutants of Saccharomyces cerevisiae that display increased rates of chromosome loss. In addition to mutations in the tubulin-encoding TUB genes, we found mutations in the CIN1, CIN2, and CIN4 genes. These genes h...

Topics

Benomyl
Chromosomes, Fungal
Cold Temperature
Fungal Proteins
Genes, Fungal
Microscopy, Fluorescence
Microtubules
Mitosis
Mutation
Recombination, Genetic
Saccharomyces cerevisiae
Spindle Apparatus
Tubulin

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