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Article

Mutational activation of c-Ha-ras gene in squamous cell carcinomas of rat Zymbal gland induced by carcinogenic heterocyclic amines.

Molecular carcinogenesis - 1 Jan 1991

Kudo M, Ogura T, Esumi H, Sugimura T

Abstract excerpt

The activation of the c-Ha-ras gene and its carcinogen specificity were examined in squamous cell carcinomas (SCCs) induced by the mutagenic heterocyclic amines 2-amino-3-methylimidazo [4,5-f]quinoline (IQ),2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) in the Zymbal gland in rats. DNA fragments of the c-Ha-ras gene were amplified from formalin-fixed...

Topics

Animals
Carcinoma, Squamous Cell
Codon
Ear Neoplasms
Ear, External
Gene Expression Regulation, Neoplastic
Genes, ras
Male
Mutagens
Mutation
Quinolines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quinoxalines

Rats

Rats, Inbred F344

Sebaceous Gland Neoplasms

Source

Identifiers

PMID: 2009133
DOI: 10.1002/mc.2940040107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2009133-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutational activation of c-Ha-ras gene in squamous cell carcinomas of rat Zymbal gland induced by carcinogenic heterocyclic amines.PMID 2009133Read ↗

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