Article
DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in colon, bladder, and kidney of congenic mice differing in Ah responsiveness and N-acetyltransferase genotype.
Cancer research - 15 Jul 1995
Nerurkar P V, Schut H A, Anderson L M, Riggs C W, Snyderwine E G, Thorgeirsson S S, Weber W W, Rice J M, Levy G N
Abstract excerpt
Heterocyclic amines, suspected as cancer initiators, require metabolic activation to exert genotoxicity. The food carcinogen 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) undergoes activation via N-hydroxylation by cytochrome P450 1A2, followed by O-esterification by N-acetyltransferase. We exami...
Topics
- Acetylation
- Animals
- Arylamine N-Acetyltransferase
- Carcinogens
- Colon
- Cytochrome P-450 CYP1A2
- Cytochrome P-450 Enzyme System
- DNA
- DNA Adducts
- Female
- Genotype
- Kidney
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA