Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals.

Environmental health perspectives - 1 May 1996

Nagao M, Wakabayashi K, Ushijima T, Toyota M, Totsuka Y, Sugimura T

Abstract excerpt

Heterocyclic amines (HCAs) are mutagens/carcinogens to which humans are exposed on almost a daily basis. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhlP) is the most abundant of the various carcinogenic HCAs (present at a level of 0.56 to 69.2 ng/g of cooked meat or fish), with 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx) following it at 0.64 to 6.44 ng/g. HCAs have been found in the urine of...

Topics

Amines
Animals
Carcinogens, Environmental
DNA Adducts
Environmental Exposure
Food Contamination
Heterocyclic Compounds
Humans
Imidazoles
Mutagens
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasms

Quinoxalines

Source

Open in PubMed Open full text

Identifiers

PMID: 8781372
DOI: 10.1289/ehp.96104s3497
PMCID: PMC1469625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals.PMID 8781372Read ↗

Genetic alterations in rat colon tumors induced by heterocyclic amines.Semantic proximity Read ↗

Studies on mammary carcinogenesis induced by a heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in mice and rats.Semantic proximity Read ↗

Modeling human colon cancer in rodents using a food‐borne carcinogen, PhIPSemantic proximity Read ↗

Food-derived mutagens and carcinogens.Semantic proximity Read ↗

Genetic polymorphisms in metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine.Semantic proximity Read ↗

Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cyclooxygenase-2 and inducible nitric oxide synthase.Semantic proximity Read ↗

Carcinogenicity of aminophenylnorharman, a possible novel endogenous mutagen, formed from norharman and aniline, in F344 rats.Semantic proximity Read ↗

Biological significance of trace levels of mutagenic heterocyclic aromatic amines in human diet: a critical review.Semantic proximity Read ↗

Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.Semantic proximity Read ↗

Beta-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice.Semantic proximity Read ↗

High potency of bioactivation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mouse colon epithelial cells with Apc(Min) mutation.Semantic proximity Read ↗

Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.