Article
Rat p53 gene mutations in primary Zymbal gland tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline, a food mutagen.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1992
Makino H, Ishizaka Y, Tsujimoto A, Nakamura T, Onda M, Sugimura T, Nagao M
Abstract excerpt
There are reports of p53 gene mutations in various human cancers but not in rat tumor cell lines or rat primary tumor tissue. We found a p53 gene mutation in a cell line of a spontaneous squamous cell carcinoma of the rat Zymbal gland, SCC131, at codon 171 by direct sequencing of cDNA fragments a...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- DNA
- DNA, Neoplasm
- Genes, p53
- In Vitro Techniques
- Molecular Sequence Data
- Mutation
- Neoplasms, Experimental
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Quinolines
- Rats