Article
Rat p53 gene mutations in primary Zymbal gland tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline, a food mutagen.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1992
Makino H, Ishizaka Y, Tsujimoto A, Nakamura T, Onda M, Sugimura T, Nagao M
Abstract excerpt
There are reports of p53 gene mutations in various human cancers but not in rat tumor cell lines or rat primary tumor tissue. We found a p53 gene mutation in a cell line of a spontaneous squamous cell carcinoma of the rat Zymbal gland, SCC131, at codon 171 by direct sequencing of cDNA fragments amplified by PCR. We tested for p53 gene mutations in 15 primary Zymbal gland tumors induced by...
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