Article
Detection of a Ha-ras point mutation by polymerase chain reaction-single strand conformation polymorphism analysis in 2-amino-3,4-dimethylimidazo[4,5-f]quinoline-induced mouse forestomach tumors.
Cancer letters - 29 Feb 1992
Makino H, Ochiai M, Caignard A, Ishizaka Y, Onda M, Sugimura T, Nagao M
Abstract excerpt
Ha-ras activation in forestomach squamous cell carcinomas of CDF1 mice induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), one of the heterocyclic amines isolated from broiled sardine was analyzed. Mutations were detected in two of three primary original carcinomas and two of four cell...
Topics
- Animals
- Base Sequence
- Carcinoma, Squamous Cell
- Codon
- DNA, Neoplasm
- DNA, Single-Stranded
- Exons
- Genes, ras
- Mice
- Molecular Sequence Data
- Mutagens
- Mutation