Article
Agreement of mutational characteristics of heterocyclic amines in lacI of the Big Blue mouse with those in tumor related genes in rodents.
Carcinogenesis - 1 Apr 1997
Okonogi H, Ushijima T, Zhang X B, Heddle J A, Suzuki T, Sofuni T, Felton J S, Tucker J D, Sugimura T, Nagao M
Abstract excerpt
The mutational spectra of carcinogenic heterocyclic amines (HCAs), 2-amino-3,4-dimethylimidazo[4,5-b]quinoline (MeIQ), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-9H-pyrido[2,3-b]indole (A alphaC) were studied in the colon of Big Blue mice. In 90, 115 and 105 lacI mutants f...
Topics
- Animals
- Bacterial Proteins
- Carbolines
- Cell Division
- Escherichia coli Proteins
- Female
- Genes, APC
- Genes, ras
- Imidazoles
- Lac Repressors
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mutation
- Neoplasms, Experimental