High frequency and low specificity of ras gene mutations in rat Zymbal's gland tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline.

doi:10.1093/carcin/14.7.1355

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Article

High frequency and low specificity of ras gene mutations in rat Zymbal's gland tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline.

Carcinogenesis - 1 Jul 1993

Takahashi M, Minamoto T, Sugimura T, Esumi H

Abstract excerpt

The activating mutations of all three ras genes in rat Zymbal's gland tumors induced by a food mutagen, 2-amino-3-methylimidazo[4,5- f]quinoline (IQ) were analyzed. DNA fragments of the Ha-ras, Ki-ras and N-ras oncogenes were amplified from formalin-fixed and paraffin-embedded tissues by the poly...

Topics

Animals
Base Sequence
Carcinogens
Carcinoma, Squamous Cell
DNA, Single-Stranded
Ear Neoplasms
Genes, ras
Male
Molecular Sequence Data
Mutation
Papilloma
Quinolines
Rats
Rats, Inbred F344
Sebaceous Gland Neoplasms

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