Article
Metabolic activation, DNA adducts, and H-ras mutations in human neoplastic and non-neoplastic laryngeal tissue.
Journal of cellular biochemistry. Supplement - 1 Jan 1993
Stern S J, Degawa M, Martin M V, Guengerich F P, Kaderlik R K, Ilett K F, Breau R, McGhee M, Montague D, Lyn-Cook B
Abstract excerpt
Metabolic activation, DNA adducts, and H-ras mutations were examined in human laryngeal tissue (n = 16) from both smoker and non/ex-smoker patients with laryngeal cancer. DNA adducts detected by 32P-postlabelling were evident only in smokers (n = 13); in fact, smoking cessation for as little as 1...
Topics
- 4-Aminobenzoic Acid
- Benzo(a)pyrene
- Biotransformation
- DNA Damage
- DNA, Neoplasm
- Genes, ras
- Humans
- Laryngeal Neoplasms
- Larynx
- Molecular Structure
- Mutation
- Naphthols
- Smoking
- Sulfamethazine
- Sulfotransferases