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Article

17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagy.

PloS one - 18 Jan 2010

Riedel Michael, Goldbaum Olaf, Schwarz Lisa, Schmitt Sebastian, Richter-Landsberg Christiane

Abstract excerpt

BACKGROUND: The accumulation and aggregation of alpha-synuclein in nerve cells and glia are characteristic features of a number of neurodegenerative diseases termed synucleinopathies. alpha-Synuclein is a highly soluble protein which in a nucleation dependent process is capable of self-aggregatio...

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Identifiers

PMID: 20090920
DOI: 10.1371/journal.pone.0008753
PMCID: PMC2807466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20090920-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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