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Article

17-AAG increases autophagic removal of mutant androgen receptor in spinal and bulbar muscular atrophy.

Neurobiology of disease - 1 Jan 2011

Rusmini Paola, Simonini Francesca, Crippa Valeria, Bolzoni Elena, Onesto Elisa, Cagnin Monica, Sau Daniela, Ferri Nicola, Poletti Angelo

Abstract excerpt

Several types of motorneuron diseases are linked to neurotoxic mutant proteins. These acquire aberrant conformations (misfolding) that trigger deleterious downstream events responsible for neuronal dysfunction and degeneration. The pharmacological removal of misfolded proteins might thus be useful in these diseases. We utilized a peculiar motorneuronal disease model, spinobulbar muscular atrophy (SBMA), in which...

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Source

Identifiers

PMID: 20816782
DOI: 10.1016/j.nbd.2010.08.023

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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