Article
Polyglutamine-mediated aggregation and cell death.
Biochemical and biophysical research communications - 16 Jun 2000
de Cristofaro T, Affaitati A, Feliciello A, Avvedimento E V, Varrone S
Abstract excerpt
The expansion of CAG repeats is the genetic defect underlying eight neurodegenerative diseases. A common feature of these disorders is the presence of intracellular aggregates in neuronal cells. It is still unclear the significance of these cellular inclusions in the neurodegenerative process, since cell death without aggregate formation has been reported. We have constructed a synthetic fusion protein containing...
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