Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alpha-synuclein aggregation involves a bafilomycin A<sub>1</sub>-sensitive autophagy pathway

13 May 2012

Abstract excerpt

Synucleinopathies like Parkinson disease and dementia with Lewy bodies (DLB) are characterized by α-synuclein aggregates within neurons (Lewy bodies) and their processes (Lewy neurites). Whereas α-synuclein has been genetically linked to the disease process, the pathological relevance of α-synuclein aggregates is still debated. Impaired degradation is considered to result in aggregation of α-synuclein. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Lysosomal Storage Disorders Research
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22647715
DOI: 10.4161/auto.19371

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alpha-synuclein aggregation involves a bafilomycin A<sub>1</sub>-sensitive autophagy pathwayPMID 22647715Read ↗

The Parkinson disease protein α-synuclein inhibits autophagySemantic proximity Read ↗

Alpha-Synuclein: The Spark That Flames Dopaminergic Neurons, In Vitro and In Vivo EvidenceSemantic proximity Read ↗

α‐Synuclein metabolism and aggregation is linked to ubiquitin‐independent degradation by the proteasomeSemantic proximity Read ↗

Distinct Roles<i>In Vivo</i>for the Ubiquitin–Proteasome System and the Autophagy–Lysosomal Pathway in the Degradation of α-SynucleinSemantic proximity Read ↗

Alpha-synuclein degradation by autophagic pathways: A potential key to Parkinson’s Disease pathogenesisSemantic proximity Read ↗

Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.Semantic proximity Read ↗

Accumulation and clearance of alpha-synuclein aggregates demonstrated by time-lapse imaging.Semantic proximity Read ↗

Genetic and Chemical Activation of TFEB Mediates Clearance of Aggregated α-SynucleinSemantic proximity Read ↗

α-Synuclein impairs macroautophagy: implications for Parkinson’s diseaseSemantic proximity Read ↗

LAMP2A as a therapeutic target in Parkinson diseaseSemantic proximity Read ↗

Alpha synuclein aggregation: is it the toxic gain of function responsible for neurodegeneration in Parkinson's disease?Semantic proximity Read ↗

Glucocerebrosidase deficiency promotes release of α-synuclein fibrils from cultured neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.