Article
Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments.
FEBS letters - 27 Nov 1998
El-Agnaf O M, Jakes R, Curran M D, Middleton D, Ingenito R, Bianchi E, Pessi A, Neill D, Wallace A
Abstract excerpt
Alpha-synuclein (alpha-syn) protein and a fragment of it, called NAC, have been found in association with the pathological lesions of a number of neurodegenerative diseases. Recently, mutations in the alpha-syn gene have been reported in families susceptible to an inherited form of Parkinson's di...
Topics
- Amyloid
- Apoptosis
- Benzothiazoles
- Biopolymers
- Cell Nucleus
- Cell Survival
- Circular Dichroism
- Humans
- Microscopy, Electron
- Mutation
- Nerve Tissue Proteins
- Neuroblastoma
- Neurodegenerative Diseases
- Neurons