Article

Acrylamide Induces Protein Aggregation in CNS through Suppression of FoxO1-mediated Autophagy

2022-08-01

Abstract excerpt

<h4>ABSTRACT</h4> Proteotoxic stress is a major stimulus and risk factor for the neuropathogenesis in central nervous system (CNS), which is tightly associated with neurodegenerative diseases. Here, we identify acrylamide (ACR), a type-2 alkene that is commonly detected in deep-fried starch food and used in water industry and biomedical laboratories, as a potent and universal inducer of proteotoxic stress in mous...

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Literature Corpus work: ec86529c-d3f7-5d57-aa6f-c23715ed5d0e
DOI: 10.1101/2022.07.29.498756

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