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Article

PTIP promotes DNA double‐strand break repair through homologous recombination

19 Jan 2010

Abstract excerpt

PTIP (Pax2 transactivation domain-interacting protein) is a large nuclear protein containing six BRCT (BRCA1 C-Terminal) domains. PTIP is recruited to DNA-damage sites through its BRCT domains and thus has been implicated in the DNA damage response. To define the function of PTIP in DNA repair, we disrupted the PTIP gene of the chicken DT40 B cell line. PTIP mutant (PTIP(-/-/-) ) cells displayed phenotypes...

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Identifiers

PMID: 20088963
DOI: 10.1111/j.1365-2443.2009.01379.x

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