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Article

BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination.

PloS one - 1 Jan 2015

Hoa Nguyen Ngoc, Kobayashi Junya, Omura Masato, Hirakawa Mayumi, Yang Soo-Hyun, Komatsu Kenshi, Paull Tanya T, Takeda Shunichi, Sasanuma Hiroyuki

Abstract excerpt

Homologous recombination plays a key role in the repair of double-strand breaks (DSBs), and thereby significantly contributes to cellular tolerance to radiotherapy and some chemotherapy. DSB repair by homologous recombination is initiated by 5' to 3' strand resection (DSB resection), with nucleases generating the 3' single-strand DNA (3'ssDNA) at DSB sites. Genetic studies of Saccharomyces cerevisiae demonstrate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25909997
DOI: 10.1371/journal.pone.0124495
PMCID: PMC4409214

Genes

BRCA1

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Related research

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BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination.PMID 25909997Read ↗

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