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Article

The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.

The Journal of cell biology - 27 May 2013

Reczek Colleen R, Szabolcs Matthias, Stark Jeremy M, Ludwig Thomas, Baer Richard

Abstract excerpt

The CtIP protein facilitates homology-directed repair (HDR) of double-strand DNA breaks (DSBs) by initiating DNA resection, a process in which DSB ends are converted into 3'-ssDNA overhangs. The BRCA1 tumor suppressor, which interacts with CtIP in a phospho-dependent manner, has also been implica...

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Share to BRCA1 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

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Source

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Identifiers

PMID: 23712259
DOI: 10.1083/jcb.201302145
PMCID: PMC3664708

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23712259-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.PMID 23712259Read ↗

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