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Article

Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells.

The EMBO journal - 22 Mar 2006

Hochegger Helfrid, Dejsuphong Donniphat, Fukushima Toru, Morrison Ciaran, Sonoda Eiichiro, Schreiber Valérie, Zhao Guang Yu, Saberi Alihossein, Masutani Mitsuko, Adachi Noritaka, Koyama Hideki, de Murcia Gilbert, Takeda Shunichi

Abstract excerpt

Parp-1 and Parp-2 are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). Their involvement in double-strand break (DSB) repair mediated by homologous recombination (HR) or nonhomologous end joining (NHEJ) remains unclear. We addressed this question using chicken DT40 cells, which have the advantage of carrying only a PARP-1 gene but not a PARP-2 gene. We found that...

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Identifiers

PMID: 16498404
DOI: 10.1038/sj.emboj.7601015
PMCID: PMC1422167

Genes

SSB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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