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Article

A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival

1 Jan 2002

Abstract excerpt

BRCA1 carboxyl-terminal (BRCT) motifs are present in a number of proteins involved in DNA repair and/or DNA damage-signaling pathways. Human DNA topoisomerase II binding protein 1 (TopBP1) contains eight BRCT motifs and shares sequence similarity with the fission yeast Rad4/Cut5 protein and the budding yeast DPB11 protein, both of which are required for DNA damage and/or replication checkpoint controls. We report...

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Identifiers

PMID: 11756551
DOI: 10.1128/mcb.22.2.555-566.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell SurvivalPMID 11756551Read ↗

BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage ResponseSemantic proximity Read ↗

Human TopBP1 Ensures Genome Integrity during Normal S PhaseSemantic proximity Read ↗

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1Semantic proximity Read ↗

Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancerSemantic proximity Read ↗

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligandsSemantic proximity Read ↗

The BRCT domain is a phospho-protein binding domain.Semantic proximity Read ↗

TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivitySemantic proximity Read ↗

Regulation of p53 by TopBP1: a Potential Mechanism for p53 Inactivation in CancerSemantic proximity Read ↗

BRCT domains: phosphopeptide binding and signaling modules.Semantic proximity Read ↗

BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβSemantic proximity Read ↗

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosisSemantic proximity Read ↗

An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.Semantic proximity Read ↗

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