Article
Theoretical study of lipid biosynthesis in wild-type Escherichia coli and in a protoplast-type L-form using elementary flux mode analysis.
The FEBS journal - 1 Feb 2010
Kenanov Dimitar, Kaleta Christoph, Petzold Andreas, Hoischen Christian, Diekmann Stephan, Siddiqui Roman A, Schuster Stefan
Abstract excerpt
In the present study, we investigated lipid biosynthesis in the bacterium Escherichia coli by mathematical modeling. In particular, we studied the interaction between the subsystems producing unsaturated and saturated fatty acids, phospholipids, lipid A, and cardiolipin. The present analysis was carried out both for the wild-type and for several in silico knockout mutants, using the concept of elementary flux...
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