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Article

Metabolite essentiality elucidates robustness of Escherichia coli metabolism.

Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2007

Kim Pan-Jun, Lee Dong-Yup, Kim Tae Yong, Lee Kwang Ho, Jeong Hawoong, Lee Sang Yup, Park Sunwon

Abstract excerpt

Complex biological systems are very robust to genetic and environmental changes at all levels of organization. Many biological functions of Escherichia coli metabolism can be sustained against single-gene or even multiple-gene mutations by using redundant or alternative pathways. Thus, only a limited number of genes have been identified to be lethal to the cell. In this regard, the reaction-centric gene deletion...

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PMID: 17698812
DOI: 10.1073/pnas.0703262104
PMCID: PMC1947999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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