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Article

The global transcriptional regulatory network for metabolism in Escherichia coli exhibits few dominant functional states.

Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2005

Barrett Christian L, Herring Christopher D, Reed Jennifer L, Palsson Bernhard O

Abstract excerpt

A principal aim of systems biology is to develop in silico models of whole cells or cellular processes that explain and predict observable cellular phenotypes. Here, we use a model of a genome-scale reconstruction of the integrated metabolic and transcriptional regulatory networks for Escherichia coli, composed of 1,010 gene products, to assess the properties of all functional states computed in 15,580 different...

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Identifiers

PMID: 16357206
DOI: 10.1073/pnas.0505231102
PMCID: PMC1323155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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