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Article

A Complete Pathway Model for Lipid A Biosynthesis in Escherichia coli.

PloS one - 1 Jan 2014

Emiola Akintunde, George John, Andrews Steven S

Abstract excerpt

Lipid A is a highly conserved component of lipopolysaccharide (LPS), itself a major component of the outer membrane of Gram-negative bacteria. Lipid A is essential to cells and elicits a strong immune response from humans and other animals. We developed a quantitative model of the nine enzyme-catalyzed steps of Escherichia coli lipid A biosynthesis, drawing parameters from the experimental literature. This model...

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Identifiers

PMID: 25919634
DOI: 10.1371/journal.pone.0121216
PMCID: PMC4412817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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