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Article

Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding.

Human molecular genetics - 15 Aug 2008

Burdick Katherine E, Kamiya Atsushi, Hodgkinson Colin A, Lencz Todd, DeRosse Pamela, Ishizuka Koko, Elashvili Sarah, Arai Hiroyuki, Goldman David, Sawa Akira, Malhotra Anil K

Abstract excerpt

DISC1 influences susceptibility to psychiatric disease and related phenotypes. Intact functions of DISC1 and its binding partners, NDEL1 and NDE1, are critical to neurodevelopmental processes aberrant in schizophrenia (SZ). Despite evidence of an NDEL1-DISC1 protein interaction, there have been no investigations of the NDEL1 gene or the relationship between NDEL1 and DISC1 in SZ. We genotyped six NDEL1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18469341
DOI: 10.1093/hmg/ddn146
PMCID: PMC2486442

Genes

DISC1
NDEL1
NDE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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