Article
Analysis of the SIM1 contribution to polygenic obesity in the French population.
Obesity (Silver Spring, Md.) - 1 Aug 2010
Ghoussaini Maya, Stutzmann Fanny, Couturier Cyril, Vatin Vincent, Durand Emmanuelle, Lecoeur Cécile, Degraeve Franck, Heude Barbara, Tauber Maithé, Hercberg Serge, Levy-Marchal Claire, Tounian Patrick, Weill Jacques, Traurig Michael, Bogardus Clifton, Baier Leslie J, Michaud Jacques L, Froguel Philippe, Meyre David
Abstract excerpt
SIM1 (single-minded 1) haploinsufficiency is responsible for obesity in both humans and mice, but the contribution of frequent DNA variation to polygenic obesity is unknown. Sequencing of all exons, exon/intron boundaries, 870 base pairs (bp) of the putative promoter, and 1,095 bp of the 3'UTR of SIM1 gene in 143 obese children and 24 control adults identified 13 common variants. After analysis of the linkage...
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