Article
Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity.
Obesity (Silver Spring, Md.) - 1 Jan 2012
Clark Stephen J, Falchi Mario, Olsson Bob, Jacobson Peter, Cauchi Stéphane, Balkau Beverley, Marre Michel, Lantieri Olivier, Andersson Johanna C, Jernås Margareta, Aitman Timothy J, Richardson Sylvia, Sjöström Lars, Wong Hang Y, Carlsson Lena M S, Froguel Philippe, Walley Andrew J
Abstract excerpt
Recent studies have reported associations of sirtuin 1 (SIRT1) single nucleotide polymorphisms (SNPs) to both obesity and BMI. This study was designed to investigate association between SIRT1 SNPs, SIRT1 gene expression and obesity. Case-control analyses were performed using 1,533 obese subjects (896 adults, BMI >40 kg/m(2) and 637 children, BMI >97th percentile for age and sex) and 1,237 nonobese controls, all...
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