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Article

Studies of the SIM1 gene in relation to human obesity and obesity-related traits.

International journal of obesity (2005) - 1 Mar 2007

Hung C-C C, Luan J, Sims M, Keogh J M, Hall C, Wareham N J, O'Rahilly S, Farooqi I S

Abstract excerpt

OBJECTIVE: The single-minded 1 (SIM1) is a basic helix-loop-helix transcription factor, which plays a critical role in the development of the paraventricular nucleus (PVN) of the hypothalamus. SIM1-deficient mice have a hypocellular PVN and are severely obese with increased food intake. DESIGN: We examined whether variants in the SIM1 gene might be associated with severe early-onset obesity in humans. Two hundred...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16924270
DOI: 10.1038/sj.ijo.0803443

Genes

SIM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Studies of the SIM1 gene in relation to human obesity and obesity-related traits.PMID 16924270Read ↗

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Profound obesity associated with a balanced translocation that disrupts the SIM1 gene.Semantic proximity Read ↗

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Cumulative Effects of Genetic Variants Detected in a Child with Early-Onset Non-Syndromic Obesity Due to SIM-1 Gene MutationSemantic proximity Read ↗

Sim1 Haploinsufficiency Impairs Melanocortin-Mediated Anorexia and Activation of Paraventricular Nucleus NeuronsSemantic proximity Read ↗

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SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake.Semantic proximity Read ↗

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