Article

Oligogenic inheritance in severe adult obesity

2022-12-21

Abstract excerpt

<title>Abstract</title> <p>The genetic architecture of extreme non-syndromic obesity in adults remains to be elucidated. A range of genes are known to cause monogenic obesity but, even when pathogenic mutations are present, there may be variable penetrance. Here, we present a family where initial discovery of a proband with a mutation in <italic>SH2B1</italic> could have led to inaccurate genetic counselling. Who...

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Literature Corpus work: a8a80233-8351-54df-895a-3098113d26e2
DOI: 10.21203/rs.3.rs-2355360/v1

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