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Article

Replication and extension of association between common genetic variants in SIM1 and human adiposity.

Obesity (Silver Spring, Md.) - 1 Dec 2011

Swarbrick Michael M, Evans Daniel S, Valle Maria I, Favre Hélène, Wu Shi-Hsuan, Njajou Omer T, Li Rongling, Zmuda Joseph M, Miljkovic Iva, Harris Tamara B, Kwok Pui-Yan, Vaisse Christian, Hsueh Wen-Chi

Abstract excerpt

Haplo-insufficiency of the bHLH (basic helix-loop-helix) transcription factor single-minded 1 (SIM1) causes severe obesity in mice and humans. We hypothesized that common genetic variations in/near SIM1 could exert more subtle effects on its function and associate with human adiposity. First, SIM1 coding regions were sequenced in severely obese subjects, and two common nonsynonymous single-nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21512513
DOI: 10.1038/oby.2011.79
PMCID: PMC4646950

Genes

SIM1
ARNT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Replication and extension of association between common genetic variants in SIM1 and human adiposity.PMID 21512513Read ↗

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