Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional characterization of SIM1-associated enhancers.

Human molecular genetics - 1 Apr 2014

Kim Mee J, Oksenberg Nir, Hoffmann Thomas J, Vaisse Christian, Ahituv Nadav

Abstract excerpt

Haploinsufficiency of the single-minded homology 1 (SIM1) gene in humans and mice leads to severe obesity, suggesting that altered expression of SIM1, by way of regulatory elements such as enhancers, could predispose individuals to obesity. Here, we identified transcriptional enhancers that could regulate SIM1, using comparative genomics coupled with zebrafish and mouse transgenic enhancer assays. Owing to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haploinsufficiency

Share to Hypothalamus

Share to Obesity, Morbid

Share to Regulatory Sequences, Nucleic Acid

Share to Repressor Proteins

Share to Zebrafish

Source

Open in PubMed Open full text

Identifiers

PMID: 24203700
DOI: 10.1093/hmg/ddt559
PMCID: PMC3943516

Genes

SIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional characterization of SIM1-associated enhancers.PMID 24203700Read ↗

Mutation screen of the SIM1 gene in pediatric patients with early-onset obesity.Semantic proximity Read ↗

Studies of the SIM1 gene in relation to human obesity and obesity-related traits.Semantic proximity Read ↗

Promoter or enhancer activation by CRISPRa rescues haploinsufficiency caused obesitySemantic proximity Read ↗

Genetic analysis of single-minded 1 gene in early-onset severely obese children and adolescents.Semantic proximity Read ↗

Cumulative Effects of Genetic Variants Detected in a Child with Early-Onset Non-Syndromic Obesity Due to SIM-1 Gene MutationSemantic proximity Read ↗

Integrative single-cell characterization of hypothalamus sex-differential and obesity-associated genes and regulatory elementsSemantic proximity Read ↗

Profound obesity associated with a balanced translocation that disrupts the SIM1 gene.Semantic proximity Read ↗

Analysis of the SIM1 contribution to polygenic obesity in the French population.Semantic proximity Read ↗

Genetic variant rs17185536 regulates SIM1 gene expression in human brain hypothalamusSemantic proximity Read ↗

SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake.Semantic proximity Read ↗

Replication and extension of association between common genetic variants in SIM1 and human adiposity.Semantic proximity Read ↗

Identification of the downstream targets of SIM1 and ARNT2, a pair of transcription factors essential for neuroendocrine cell differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.