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Article

Genetic analysis of single-minded 1 gene in early-onset severely obese children and adolescents.

PloS one - 1 Jan 2017

Stanikova Daniela, Buzga Marek, Krumpolec Patrik, Skopkova Martina, Surova Martina, Ukropcova Barbara, Ticha Lubica, Petrasova Miroslava, Gabcova Dominika, Huckova Miroslava, Piskorova Lucie, Bozensky Jan, Mokan Marian, Ukropec Jozef, Zavacka Ivona, Klimes Iwar, Stanik Juraj, Gasperikova Daniela

Abstract excerpt

BACKGROUND: Inactivating mutations of the hypothalamic transcription factor singleminded1 (SIM1) have been shown as a cause of early-onset severe obesity. However, to date, the contribution of SIM1 mutations to the obesity phenotype has only been studied in a few populations. In this study, we screened the functional regions of SIM1 in severely obese children of Slovak and Moravian descent to determine if genetic...

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Identifiers

PMID: 28472148
DOI: 10.1371/journal.pone.0177222
PMCID: PMC5417716

Genes

SIM1

Variants

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