Article

Genome-wide association study provides novel insight into the genetic architecture of severe obesity

2025-02-26

Abstract excerpt

<h4>ABSTRACT</h4> Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic diseases (CMD) and several cancers, with a disproportionate impact on marginalized populations. SevO is an understudied global health disease, limiting knowledge about its mechanisms and impacts. In genome-wide association study (GWAS) meta-analyses of the tail end of the BMI distribution (≥95 th percentil...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 140712f3-727b-53c1-8341-1155ead76486
DOI: 10.1101/2025.02.25.25322870

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study provides novel insight into the genetic architecture of severe obesityDOI 10.1101/2025.02.25.25322870Read

Genome-wide association study provides novel insight into the genetic architecture of severe obesity.Semantic proximity Read

Quantifying the phenome-wide disease burden of obesity using electronic health records and genomics.Semantic proximity Read

Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities.Semantic proximity Read

Genomics reveals eleven obesity endotypes with distinct biological and phenotypic signaturesSemantic proximity Read

Genomics and phenomics of body mass index reveals a complex disease network.Semantic proximity Read

Association of obesity and its genetic predisposition with the risk of severe COVID-19: Analysis of population-based cohort data.Semantic proximity Read

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.Semantic proximity Read

Genome-wide analysis and polygenic prediction of clinical obesity and comparison with body mass indexSemantic proximity Read

Phenome-wide screening of GWAS data reveals the complex causal architecture of obesitySemantic proximity Read

Genetic studies of body mass index yield new insights for obesity biology.Semantic proximity Read

Contribution of 32 GWAS-identified common variants to severe obesity in European adults referred for bariatric surgery.Semantic proximity Read

The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations.Semantic proximity Read