Article
Mutation screen of the SIM1 gene in pediatric patients with early-onset obesity.
International journal of obesity (2005) - 1 Jul 2014
Zegers D, Beckers S, Hendrickx R, Van Camp J K, de Craemer V, Verrijken A, Van Hoorenbeeck K, Verhulst S L, Rooman R P, Desager K N, Massa G, Van Gaal L F, Van Hul W
Abstract excerpt
BACKGROUND: The transcription factor SIM1 (Single-minded 1) is involved in the control of food intake and in the pathogenesis of obesity. In mice, Sim1 is involved in the development of the paraventricular nucleus, and Sim1 deficiency leads to severe obesity and hyperphagia. In humans, chromosomal abnormalities in the SIM1 gene region have been reported in obese individuals. Furthermore, recent data also suggest...
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