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Article

Common variation in SIM1 is reproducibly associated with BMI in Pima Indians.

Diabetes - 1 Jul 2009

Traurig Michael, Mack Janel, Hanson Robert L, Ghoussaini Maya, Meyre David, Knowler William C, Kobes Sayuko, Froguel Philippe, Bogardus Clifton, Baier Leslie J

Abstract excerpt

OBJECTIVE: Haploinsufficiency of SIM1 is a cause of rare monogenic obesity. To assess the role of SIM1 in polygenic obesity, this gene was analyzed in the Pima Indian population, which has a high prevalence of obesity. RESEARCH DESIGN AND METHODS: SIM1 was sequenced in 96 individuals. Variants (n = 46) were genotyped in a population-based sample of 3,250 full-heritage Pima Indians and in a separate replication...

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Identifiers

PMID: 19401419
DOI: 10.2337/db09-0028
PMCID: PMC2699863

Genes

SIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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