Article
Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement.
Biochemical Society transactions - 1 Feb 2010
McDonald Angela, Fogarty Sarah, Leclerc Isabelle, Hill Elaine V, Hardie D Grahame, Rutter Guy A
Abstract excerpt
Glucose-stimulated insulin secretion from pancreatic beta-cells requires the kinesin-1/Kif5B-mediated transport of insulin granules along microtubules. 5'-AMPK (5'-AMP-activated protein kinase) is a heterotrimeric serine/threonine kinase which is activated in beta-cells at low glucose concentrati...
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