Article
Insulin-induced GLUT4 movements in C2C12 myoblasts: evidence against a role of conventional kinesin motor proteins.
The Kobe journal of medical sciences - 23 May 2008
Takazawa Kazuo, Noguchi Tetsuya, Hosooka Tetsuya, Yoshioka Toyo, Tobimatsu Kazutoshi, Kasuga Masato
Abstract excerpt
Insulin induces translocation of the glucose transporter GLUT4 from intracellular storage compartment to the plasma membrane via complex mechanisms that require intact cytoskeletal networks. In cultured adipocytes, conventional kinesin motor proteins have been proposed to mediate GLUT4 movements on microtubules. It remains, however, unclear whether kinesin motor system plays a similar regulatory role in myocytes....
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