Article
The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells.
PloS one - 1 Jan 2012
Wei Chongjuan, Bhattaram Varun Kumar, Igwe John C, Fleming Elizabeth, Tirnauer Jennifer S
Abstract excerpt
Orientation of mitotic spindles plays an integral role in determining the relative positions of daughter cells in a tissue. LKB1 is a tumor suppressor that controls cell polarity, metabolism, and microtubule stability. Here, we show that germline LKB1 mutation in mice impairs spindle orientation in cells of the upper gastrointestinal tract and causes dramatic mislocalization of the LKB1 substrate AMPK in mitotic...
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