Article

Microtubule-mediated GLUT4 trafficking is disrupted in insulin resistant skeletal muscle

2022-09-22

Abstract excerpt

Microtubules serve as tracks for long-range intracellular trafficking of glucose transporter 4 (GLUT4), but the role of this process in skeletal muscle and insulin resistance is unclear. Here, we used fixed and live-cell imaging to study microtubule-based GLUT4 trafficking in human and mouse muscle fibers and L6 rat muscle cells. We found GLUT4 localized along and on the microtubules in mouse and human muscle fibe...

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Identifiers and source

Literature Corpus work: ec186896-a0ec-5628-b760-38b384659300
DOI: 10.1101/2022.09.19.508621

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